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| Dosages: | Oral (SR): For Depression, Smoking cessation: Start with 150mg daily single dose in the morning. If the dosage is tolerated increase to the target dose of 300mg /day in divided doses of 150mg from day 4 onwards for Depression & day 3 for smoking Cessation. Administer successive doses every 8 hrs if no improvement in Depression is observed after 4 weeks of treatment increase to 400mg daily in 2 doses of 200mg. For Smoking Cessation continue for 7-12wks & if the person is unable to quit smoking in7 wks discontinue the treatment.
Oral (Immediate Release Tablets): Initially 200 mg/day given as 100 mg twice daily. If the dose is tolerated increase to the target dose of 300mg /day in 3 divided doses of 100mg from day 3 onwards. Successive doses to be given at intervals of 6 hours. If there is no significant improvement after 4 weeks with the target it can be increased to a max 450mg / day in divided doses of 100mg or 75mg. Administer successive doses in interval of 4 hrs Single dose should not be more than 150mg at any time.
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